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Offering Duac, Differin, Adapalene, Epiduo, Doxycycline & Lymecycline.
Cheapest in the UK. Guaranteed.
  • Duac
  • Differin
  • Epiduo
  • Doxycycline
  • Lymecycline
  • £24.00
  • £42.50
  • £27.99
  • £49.99
  • Key Information
  • Two Ingredients: Benzoyl Peroxide & Clindamcyin
    Duac is one of the most commonly prescribed acne creams. Benzoyl Peroxide and Clindamycin are the two active ingredients which work to kill bacteria which contribute to spot formation.
Adapalene 0.1% 
Adapalene 0.1%
Adapalene 0.1%
  • £32.00
  • £32.00
  • £55.00
  • £55.00
  • Key Information
  • Differin is a Retinoid
    Retinoids help to remove dead skin and increase cell turnover. Retinoids will also help reduce the signs of ageing.
Epiduo 0.1%/2.5% 
Epiduo 0.1%/2.5%
Epiduo 0.1%/2.5%
  • £33.00
  • £52.50
  • £76.50
  • Key Information
  • Two Ingredients - Benzoyl Peroxide & Adapalene
    Benzoyl Peroxide is an antiseptic which helps to kill bacteria, and Adapalene is a Retinoid. It works by removing dead skin and increasing cell turnover, and has also been found to reduce the signs of ageing. It is a bit stronger than the other creams.
  • £20.00
  • £35.00
  • £45.00
Doxycycline & Benzoyl Peroxide 5% 
Doxycycline & Adapalene 
  • Key Information
  • Take with a Topical Gel or Cream
    Doxycycline is an antibiotic and must be taken with an acne gel or cream, ideally for 3 months for the best results. You can choose to take with benzoyl peroxide or Differin.
  • £19.50
  • £28.50
  • £38.50
Lymecycline 408mg & Benzoyl Peroxide 5% 
Lymecycline & Adapalene Gel 
  • Key Information
  • Take with a Topical Gel or Cream
    Lymecycline is an antibiotic and must be taken with an acne gel or cream, ideally for 3 months for the best results. You can choose to take with benzoyl peroxide or Differin.
How severe is your acne?
If your acne is mild to moderate, we recommend topical cream or gel based options. These are commonly used first if you've not had any treatment for acne before. 

The Acne Visual Dictionary
helps understand the severity of your acne. We will ensure you have selected an appropriate treatment and give suggestions if we feel an alternative may be better for you. 

If you are getting frequent scarring you might need stronger medications, and due to the increased risk of side effects we are not able to prescribe these for you. 

What causes acne?
There are multiple factors that can cause acne to occur. Excess sebum production in the skin follicles occurs due to hormonal changes and is more comming around puberty. Accumulation of dead cells and bacteria contribute to the formation of acne and substances causing inflammation. Sometimes using make-up, skin steroids and being overweight can contribute to acne formation.

Do I need any tests for acne?
Acne is simply diagnosed by its appearance and rarely are hormones tested for acne unless there were other signs or symptoms present. Swabs taken of sites often do not help to determine the type of treatment.

Other types of Acne
There are other types of Acne which these medications may not be suitable for. If you have been diagnosed with other types of acne, for example Acne Rosacea which tends to affect older adults then you should seek further medical advice.
Acne Treatments
Duac has two ingredients, benzoyl peroxide (an antiseptic) and clindamycin (an antibiotic) and they both work to kill bacteria that contribute to the formation of acne spots. Duac comes in two strengths, which corresponds to the strength of benzoyl peroxide. 5% is a little stronger than 3%, but is associated with slightly more drying or irritation of the skin, a mild but common side effect of duac. 

Dry skin is the most commonly reported side effect, and it can be beneficial especially in people who tend to get oily skin

Differin (Adapalene)
Differin contains the active ingredient adapaelene and Isotrex contains the active ingredient Isotretinoin, which are both retinoids. Retinoids help to increase cell turnover which helps to prevent acne from developing. An added benefit is that there is scientific evidence to suggest that retinoids help signs of ageing. 

Epiduo contains the retinoid differin, and benzoyl peroxide 2.5% (which is also an ingredient of duac). 

Doxycycline & Lymecycline
Doxycycline & Lymecycline are both antibiotics which are used in moderate to severe acne when gels are not sufficient on their own. They must be used with the gels or creams. They should be taken once daily with food during the day to reduce the risk of stomach side effects. Bet results will be seen after continuous treatment between 6-12 weeks. 

If you are taking Magnsium, Iron or Zinc supplements, make sure to take them at a different time of the day as Doxycycline reduces their absorption. 

We recommend that you read the information on side effects before ordering the medication. This is abailable under the Medication Information Leaflets Section. It is usually well tolerated but common side effects can include nausea and heartburn, which tends to happen only in less than 1 in 10 of people.

How To Use The Treatments 
Acne treatments are simple to use, you should wash your face first with a gentle face wash then thinly apply the cream or gel at night time. Check out our blog post on Optimising Acne Treatments by London & Sao Paulo dermatologist Dr Murakami. 

We recommend all treatments should be used for 3 months for best results, and sometimes there are limited results until at least 6 weeks of treatment. Some creams such as retinoids tend to cause skin sensitivity earlier on in treatments, and this tends to improve during the treatment.

Effectiveness Of Treatments
With all the creams, people find a significant improvement in acne within 6-8 weeks, but best results are seen after 12 weeks. You may not get full prevention, but you should expect a more than 75% reduction in the severity and amount of spots being formed. If this is not occurring you may need to consider a stronger treatment or check the diagnosis. 

Side Effects
In all of these medications - skin irritation and slight redness of the skin may occur in the first few weeks of using. It's a bit more common in the medications with retinoid within them. These symptoms usually settle down after a few weeks though. Less than 1% sometimes do find a worsening of acne with duac. 

Reporting Side Effects 
We do not expect any signifiant or serious side effects, but if you do get any you can report side effects directly to the MHRA. We would also like to hear from you too. 

Advice for Women & Contraception
You should not use Differin, Doxycycline or Lymecycline treatments if you are trying to become pregnant, pregnant or breast feeding as the medication could harm your baby. If you are sexually active we recommend using long-term contraception to prevent pregnancy. 

Medication Information Leaflets 
Duac Medication Leaflet 
Differin Medication Leaflet
Isotrex Medication Leaflet

Epiduo Medication Leaflet
Doxycycline Medication Leaflet
Lymecycline Medication Leaflet

Other Treatment Options
Non-prescription products such as face washes may help to treat acne, and products that contain salicylic acid may help to reduce skin cell waste build up in follicles. Products containing Tea Tree Oil may also work in a similar way. 

However, there is a lack of clear evidence that these work well in persistent acne. If you are using any products from The Doctor Service, topical or tablets, we do recommend using a regular face wash, but it is important not to over wash, (maximum twice a day with lukewarm water). 

Check the antibiotic oral treatments we have available if your acne is moderate to severe. 

The Combined Oral Contraceptive pill is another option to help manage acne in women as it helps to manage hormonal causes of acne, however this option is of course only available for women, and does not work for all women who try the pill. 

Roaccutane is a medication that can be prescribed only by dermatologists and it comes at a significant risk of side effects. Regular blood tests need to be taken every 3 months to ensure that it is not toxic to the body. In cases of particularly severe acne this may be the only effective option.

The use of antibiotics
Antibiotics can do more harm than good when prescribed or taken incorrectly. Read more about our advice on antibiotic use here.
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